Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait
Identifieur interne : 003098 ( Main/Exploration ); précédent : 003097; suivant : 003099Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait
Auteurs : CHUL HYOUNG LYOO [Corée du Sud] ; Sargo Aalto [Finlande] ; Juha O. Rinne [Finlande] ; KI OOK LEE [Corée du Sud] ; SEUNG HUN OH [Corée du Sud] ; JIN WOO CHANG [Corée du Sud] ; MYUNG SIK LEE [Corée du Sud]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Congélation.
English descriptors
- KwdEn :
Abstract
Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [18F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait</title><author><name sortKey="Chul Hyoung Lyoo" sort="Chul Hyoung Lyoo" uniqKey="Chul Hyoung Lyoo" last="Chul Hyoung Lyoo">CHUL HYOUNG LYOO</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Turku PET Center, University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. 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Rinne</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Turku PET Center, University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Ki Ook Lee" sort="Ki Ook Lee" uniqKey="Ki Ook Lee" last="Ki Ook Lee">KI OOK LEE</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Konyang University Hospital</s1><s2>Daejeon</s2><s3>KOR</s3><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Seung Hun Oh" sort="Seung Hun Oh" uniqKey="Seung Hun Oh" last="Seung Hun Oh">SEUNG HUN OH</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Jin Woo Chang" sort="Jin Woo Chang" uniqKey="Jin Woo Chang" last="Jin Woo Chang">JIN WOO CHANG</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>6 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Myung Sik Lee" sort="Myung Sik Lee" uniqKey="Myung Sik Lee" last="Myung Sik Lee">MYUNG SIK LEE</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term><term>Emission tomography</term><term>Encephalon</term><term>Freezing</term><term>Motor nucleus</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Positron emission tomography</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Maladie de Parkinson</term><term>Encéphale</term><term>Noyau sousthalamique</term><term>Noyau moteur</term><term>Congélation</term><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term><term>Stimulation cérébrale profonde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Congélation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [<sup>18</sup>F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Séoul</li><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Chul Hyoung Lyoo" sort="Chul Hyoung Lyoo" uniqKey="Chul Hyoung Lyoo" last="Chul Hyoung Lyoo">CHUL HYOUNG LYOO</name></noRegion><name sortKey="Jin Woo Chang" sort="Jin Woo Chang" uniqKey="Jin Woo Chang" last="Jin Woo Chang">JIN WOO CHANG</name><name sortKey="Ki Ook Lee" sort="Ki Ook Lee" uniqKey="Ki Ook Lee" last="Ki Ook Lee">KI OOK LEE</name><name sortKey="Myung Sik Lee" sort="Myung Sik Lee" uniqKey="Myung Sik Lee" last="Myung Sik Lee">MYUNG SIK LEE</name><name sortKey="Seung Hun Oh" sort="Seung Hun Oh" uniqKey="Seung Hun Oh" last="Seung Hun Oh">SEUNG HUN OH</name></country><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name></region><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. 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